severe muscle weakness during treatment with pegylated interferon alfa for chronic hepatitis c virus infection a rare complication

background: interferons (ifns) are common therapeutics for several diseases such as viral hepatitis, multiple sclerosis and malignancy. a variety of autoimmune related side effects have been observed during ifn therapy. rare cases of myopathy, polymyositis or dermatomyositis have been reported during therapy with high doses of ifn^5. case presentation: in this report, we describe a case with severe muscle weakness but near normal muscles' enzymes during treatment of chronic hepatic c infection with pegylated ifn ^5 2a in a patient with major beta thalassemiaconclusion: this report suggests that severe weakness with normal muscles^5 enzymes may occur during ifn therapy.